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Address 1 :
Address 2 :
Title : Dr.
First Name : ZAFIRA
Last Name : CASTANO
University/Institution : BWH, Harvard Medical School
Phone # : 8572212954
Email ID : [email protected]
City : Boston
Country : United States
State : Massachusetts
Zipcode : 02115
Department : Hematology/Medicine
Company Name :
Area of Research
Breast Cancer Research
Area of Expertise
Cancer Stem Cells and Tumor Microenvironment
Brief Description of Research Interest :
I am focusing my researchinto the metastasis from Breast Cancer. I am interested into address howcertain tumors instigate disseminated dormant tumoral cells outgrowth, throughthe mobilization and subsequently creation of a tumor-supportivemicroenvironment, using a unique model described by Dr. Sandra McAllister (Cell2008).

Using this unique model, I am working also incollaboration with the world-known Dr. Robert A. Weinberg, trying to addresshow primary tumors affect proliferation of diseminated metastatic cells.

During my 3 years like postdoc at BWH, I have beenvery involved into the Harvard community, representing the postdocs atBrigham and Women´s hospital, like a Postdoctoral Leadership Council member.

Also, I have created a good network of friends whoare expertise on the Cancer Stem Cell and Metastasis field, withwho I have had the pleasure to write reviews, as well as, organize Nanocursesat Harvard University, destinated to Ph.D. students (Grade 2).

Representative Publications :

1. AjonaD., CastañoZ., Garayoa M., ZudaireE., Pajares MJ., Martinez A., Cuttitta F., MontuengaLM., Pio R. Expression ofComplement Factor H by Lung Cancer Cells: Effects onthe Activation of theAlternative Pathway of Complement. Cancer Research. 2004; 64, 6310-6318.

2. Pio R, Zudaire I, Pino I, Castaño Z, Zabalegui N, VicentS,Garcia-Amigot F, Odero MD, Toledo G, Garcia-Foncillas J, Calasanz MJ,MontuengaLM. alphaCP-4, aputative tumor suppressor gene at3p21, but not its alternative splice variantalphaCP-4a, is underexpressed inlung cancer. Cancer Research. 2004; 64, 4171-4179.

3.Castaño Z.,Kypta R.M. Houskeeping proteins: limitations as references duringneuronaldifferentiation. The OpenNeuroscience Journal. 2008; 2:36-40.

4.Castaño Z., Vergara-Irigaray N, Pajares MJ, Montuenga LM.,Pio R. Expression ofaCP-4 inhibits cell cycle progression and suppressestumorigenicity in lungcancer cells invitro and in vivo. Int J Cancer. 2008;122(7):1512-20.

5. Castaño Z., Phillip R. Gordon-Weeks, KyptaR.M. Theneuron-specific isoform of glycogen synthasekinase-3beta is required for axongrowth. JNeurochem. 2010 Apr;113(1):117-30.

6. KuznetsovH., Marsh T., Markens B.A., Castaño Z., Greene-Colozzi A., Hay S.A.,BrownV.E., Richardson A.L., Signoretti S., Battinelli E.M. and McAllisterS.S.Identification of Luminal Breast Cancers that Establish a TumorSupportiveMacroenvironment Defined by Pro-Angiogenic Platelets and Bone MarrowDerivedCells. Cancer Discovery, 2012.


7. CastañoZ,Tracy K and McAllister SS. The Tumor Macroenvironment and SystemicRegulationof Breast Cancer Progression. International Journal of DevelopmentalBiology,2011.

8.-Castaño Z, FillmoreC, Kim C and McAllisterSS. The bed and the bugs:Interactions between thetumor microenvironment and cancer stem cells. SeminCancer Biol, 2012.


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