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Title : Dr.
First Name : NIMRAT
University/Institution : MIT
Email ID : [email protected]
City : Cambridge
Country : United States
State : Massachusetts
Zipcode : 02139
Department : Biology
Company Name :
Area of Research
Genetics, Biochemistry, protein chemistry
Area of Expertise
Human Genetics
Brief Description of Research Interest :
My primary research focus is to understand mechanisms of genome instability in vertebrate (human and mammalian) and yeast cells. Various environmental and endogenous sources are responsible for causing DNA damage to the genome. Under normal circumstances and depending on the damage inflicted, various DNA repair pathways such as Mismatch Repair (MMR), Nucleotide Excision Repair (NER), Base Excision Repair (BER) and the Double Strand Break Repair (DSBR) come into play to repair the damage and enable survival. At the same time, the overarching role of translesion Synthesis Polymerases (TLS) to bypass unrepaired damage contribute to cell's survival and health. I have worked variously on the DNA repair pathways and am currently focussed on studying the TLS polymerases. My long term goals are to understand in more detail cellular stress responses that are able to modulate the DNA repair pathways and contribute to cancer.
Representative Publications :

Chatterjee N., D’SouzaS., Shabab M., Heliniski G., Verdine G.L., Walker G.C. (2017). A stapled Pol κ peptide targets Rev1 and inhibits translesion synthesis. Under consideration for NSMB.

Sail V.,# Rizzo A.A.,# Chatterjee N.,# DashR.C., Ozen Z., Walker G.C., Korzhnev D.M., Hadden K. (2017).Identification of small molecule translesion synthesis inhibitors that targetthe Rev1-CT/RIR protein-protein interaction. DOI: 10.1021/acschembio.6b01144. ACS Chem Biol. (# Co-first author).

Yamanaka K.,# Chatterjee N.,# Hemann M., Walker G.C.(2017). Role of translesion DNA polymerases in cancerchemotherapy resistance and possible therapeutic strategies in inhibiting them. Accepted. Plos Genet(# Co-first author).

Chatterjee, N. (2017). Are Shwachman-diamond syndrome patientsradiosensitive? Postdoc J. 5(3),14-24

Chatterjee N. and Walker G.C. (2017). Mechanisms ofDNA damage and repair. DOI: 10.1002/em.22087. Env& Mol Mutagenesis. (Invited Article)

Chatterjee N., Lin Y., Yotnda P., Wilson J.H. (2016). Environmental Stress Induces Trinucleotide Repeat Mutagenesis  In Human Cells By Alt-Nonhomologous End Joining Repair. JMB. 10.1016/j.jmb.2016.06.004

Chatterjee N., Lin Y., Wilson J.H. (2016). Falcon anemia pathway regulates convergent transcription-induced cell death at trinucleotide repeats in human cells. PostDoc Journal. (4)5 46-54. doi.org/bjjq PMID: 27595121  PMCID: PMC5006624 

Chatterjee N., Lin Y., Wilson J.H. (2016). Mismatch repair enhances convergent transcription-induced cell death at trinucleotide repeats by activating ATR. DNA Repair. 42; 26-32. DOI.org/10.1016/j.dnarep.2016.03.016

Chatterjee N., Lin Y., Santillan B.A., Yotnda P., Wilson J.H. (2015). Environmental stress-induces trinucleotide repeat instability in human cells. PNAS. doi/10.1073/pnas.1421917112.

Chatterjee N., Williams C., Bhar S. and A. Bertuch (2015). A novel radiosensitivity phenotype in Shwachman-Diamond Syndrome is mediated by ER stress response. December 3, 2015; Blood: 126 (23).

S., Chatterjee N., LisaMirabello L., Williams C., Blanche P. Alter B.P., Giri N.,Person R., Landsverk M., Eng C., Savage S.A.and Bertuch A (2014). Denovo RPS20 mutations found in twoDiamond-Blackfan anemia patients by whole exome sequencing. American Society of Hematology. SF, California. 

Chatterjee N., Siede W. (2013).Replicating damaged DNA in eukaryotes. Cold spring Harb Prospect Biol.(Editors: Errol Friedberg, Steve Elledge, Alan Lehmann, Tomas Lindahl & Marco-Muzi-Falcone). Cold Spring Harb Perspect Biol. 2013;5:a019836.

Chatterjee N., Pabla R., Siede W.(2013). Role of polymerase η in mitochondrial mutagenesis of Saccharomycescerevisiae. Biochem Biophys Res Commun. 431:270-3.

Chatterjee N., Santillan B.A.,Wilson J.H.. (2012). Microsatellite Repeats: Canaries in the Coalmine. Stress-induced mutagenesis. David Mittelman (Ed.). Springer ISBN 978-1-4614-6279-8. Pp119-150.

Pawar V., Jingjing L., Patel N., Kaur N., Doetsch P.W., Shadel G.S., Zhang H., Siede W. (2009). Checkpoint kinasephosphorylation in response to endogenous oxidative DNA damage inrepair-deficient stationary-phase Saccharomyces cerevisiae. Mech Ageing Dev. 130:501-8.