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Address 1 :
Address 2 :
Title : Dr.
First Name : ASHLEY
Last Name : FENN
University/Institution : Harvard Medical School/MGH
Phone # : 303-870-5768
Email ID : [email protected]
City : Boston
Country : United States
State : Massachusetts
Zipcode : 02114
Department : Center for Systems Biology
Company Name :
Area of Research
Vascular Immunology
Area of Expertise
Neuroscience, Aging, Atherosclerosis
Brief Description of Research Interest :
I am broadly interested in the function and heterogeneity of the innate arm of the immune system. More specifically, I am interested in how myeloid cells initiate, accelerate, or ameliorate peripheral conditions, including atherosclerosis, and central conditions, including traumatic brain injury and depression. I received my PhD from The Ohio State University in Neuroimmunology and currently study Cardiac Immunology at Massachusetts General Hospital.
Representative Publications :

Weber G.F.*, ChoustermanB.G.*, He S.*, Fenn A.M., Nairz M., Anzai A., Brenner T., Uhle F.,Iwamoto Y., Robbins C.S., Noiret L., Maier S.L., Zönnchen T., Rahbari N.N.,Schölch S., Klotzsche A., Chavakis T., Weitz J., Hofer S., Weigand M.A., NahrendorfM., Weissleder R., and Swirski F.K. (2015). Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis. Science,347 (6227): 1260-1265.

Fenn A.M., Skendelas J., Moussa D., Muccigrosso M.M.,Eiferman D.S., and Godbout J.P. (2015). Methylene blue attenuates traumatic brain injury-associated neuro inflammation and acute depressive-like behavior in mice. Journal of Neurotrauma, 32 (2): 127-138.

Fenn A.M., Gensel J.C., Huang Y,Popovich P.G., Lifshitz J., and Godbout J.P. (2014). Immune activation promotes depression one month after diffuse brain injury: a role for primed microglia. Biological Psychiatry, 76 (7): 575-584.

Fenn A.M., Hall J.C., Gensel J.C.,Popovich P.G., and Godbout J.P. (2014). IL-4signaling drives a unique arginase+/IL-1β+ microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Rα after traumatic spinal cord injury. Journal of Neuroscience, 34 (26):8904-8917.

Fenn A.M.*, Smith K.M.*, Lovett-Racke A.E., Guerau-de-ArellanoM., Whitacre C.C., and Godbout J.P. (2013). Increased micro-RNA 29b in the aged brain correlates with the reduction of insulin-like growth factor-1 and fractalkineligand. Neurobiology of Aging, 34(12): 2748-2758.

Fenn A.M., Henry C.J., Huang Y., Dugan A., and Godbout J.P. (2012).Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired inmicroglia of aged mice. Brain Behavior and Immunity, 26: 766-777.

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